The 6 Best Cycle Support Supplements – Protect Your Liver!

Protecting your body during a cycle with steroids, prohormones, or even SARMs is essential. When you're on a cycle of one of the above, your body and organs can be in danger.

This is why it's crucial to use a cycle support supplement to protect you. If you don't use it, you are putting yourself at risk and could end up having severe adverse effects.

There are many users out there who don't understand why it's crucial to use it. In this cycle support guide, we're going to tell you why, how to use it, and which product offers the most protection.

What Is On Cycle Support?


On cycle support supplements help protect your organs during a cycle. In particular, they help protect the liver, kidneys, and heart. 

Performance enhancers such as anabolic-androgenic steroids can harm the liver and kidneys (1). They can also increase one's blood pressure (2). 

For your body to get the effects of these AAS, they pass through the liver. During this process, they can damage the liver because they're hepatoxic (3). 

You're obviously going to want to prevent this from happening, and that is where cycle support comes to help.

On Cycle Support guide

In these support products, you'll often find high-quality ingredients that can help combat these adverse effects. One of those ingredients that could help you with protection is Milk thistle (4).

It's crucial to use cycle support the entire cycle – from start to finish. I'll show you the best-formulated products that will help keep you protected.

Top 6 Cycle Support Supplements For Steroids

With a simple search, you will find that there are a lot of cycle support products. But the truth is, most of them are poorly formulated and missing key ingredients.

Steroids, prohormones, or SARMs put your organs under a lot of tension. That means a potent product needs to help protect them, meaning you shouldn't go out and pick the first best supplement you come across.

We've gone through the dozens of options out there and present you with our top 6 best cycle support supplements for steroids.

1. Defend

Cycle support supplement


After thoroughly researching and comparing the options on the market, we've concluded that Defend by Huge Nutrition is the best cycle support.

It's by far the most advanced and stacked support product you're going to find. Each ingredient contributes to keeping you protected and healthy during a cycle.

Defend Ingredients Per Serving:

  • 1000mg Milk Thistle Extract 
  • 600mg N-Acetyl-Cysteine (NAC) 
  • 500mg Peppermint Leaf Powder  
  • 250mg Saw Palmetto Extract
  • 150mg Hawthorn Berry Extract 
  • 200mg Red Clover 
  • 250mg TUDCA 

Total: 2,95 grams (2950mg) of active ingredients.

These are the exact ingredients you should be after. All these compounds have been proven to work when it comes to assisting the organs.

You won't find any useless or underdosed ingredients in Defend, which is why we're convinced it's miles ahead of the competition.

Especially TUDA is an excellent compound, and Defend is one of the very few products that actually contains it.

Because it's such an advanced and stacked formula, it's extremely popular amongst bodybuilders to use after a cycle of steroids or prohormones.

And it's even reasonably priced for what you're getting. You can buy Defend for $49.95 directly from the official Huge Nutrition site.

2. Iron Labs Cycle Support

Iron labs cycle support

Right behind Defend, we have Cycle Support by Iron Labs coming in second place. Many athletes choose this product to help assist them during a cycle of performance-enhancers.

You'll find the following ingredients per serving:

  • 900mg N-Acetyl Cystenine (NAC)
  • 825mg Milk Thistle
  • 400mg Hawthorn Berry
  • 200mg Saw Palmetto
  • 100mg Celery Seed Extract
  • 100mg Grape Seed Extract
  • 100mg Vitamin C

Total: 2,62 grams (2625mg) of active ingredients.

This formula is pretty solid, although it's missing TUDCA, an ingredient we find to be essential in cycle support supplements.

If, for some reason, you're unable to get yourselves a few bottles of Defend, this is the second-best option. We found that this product was relatively hard to source, so ensure that the place you're buying it from is legitimate.

3. Blockade


Blockade by Assault Labs is yet another cycle support for steroids and prohormones. With several cutting-edge ingredients, it's comprehensive formula can help you stay on track during a cycle.

What exactly are the cutting-edge compounds in this formula? Here's the breakdown of Blockade's ingredients:

  • 500mg Glucosamine Sulfate
  • 500mg Milk Thistle Powder
  • 500mg N-Acetyl L-Cysteine
  • 350mg Hawthorne Berry Extract
  • 150mg Saw Palmetto Powder
  • 100mg Alpha Lipoic Acid
  • 100mg SAMe
  • 75mg Grape Seed Extract
  • 75mg CoQ10

Total: 2,35 grams (2350mg) of active ingredients.

You can tell Assault Labs put a lot of effort into formulating this cycle support, as there are many key ingredients to be found in it. Therefore, we had to include it in our top 6.

You can purchase Blockade directly from Assault Labs's official site for $34.95 per bottle. We find this price to be acceptable for what you're getting.

4. Advance

Advanced Cycle Support Supplement

Advance by IronMagLabs (IML) is the third liver support for steroids on our list. It's been on the market for quite some time now and makes a reliable option.

When it comes to protecting your organs, you're going to need the best there is. Let's take a look at what this product contains.

Here's the full list of ingredients found in a serving of Advance:

  • 500mg Milk Thistle
  • 400mg N-Acetyl-Cysteine
  • 300mg Hawthorne
  • 200mg Saw Palmetto
  • 100mg Coenzyme Q10 (CoQ10)
  • 75mg Celery Seed
  • 75mg Grape Seed

Total: 1,65 grams (1650mg) of active ingredients.

As you can see, there's plenty of high-quality ingredients to be found in this product. We're talking about the protection of organs, so there needs to be enough power for everything to work correctly.

We do think the dosages of some ingredients could've been increased. There is also no TUDCA in this formula, which we found to be a downside.

You can purchase Advance cycle support from the manufacturer's official site and other online retailers.

5. Gear Support

Gear Support

Coming up next is Gear Support by Blackstone Labs, a well-known player in the bodybuilding supplement industry.

Cycles with performance-enhancers can give you massive gains, but they also come with plenty of risks. It's essential to prepare and protect yourselves from these adverse effects, which is why these products were created. 

Gear Support Ingredients:

  • 400mg N-Acetyl L-Cysteine
  • 300mg Hawthorne Flower & Leaf Extract
  • 200mg Saw Palmetto
  • 100mg Red Clover
  • 75mg Celery Extract 4:1
  • 75mg Grape Seed Extract

Total: 1,15 grams (1150mg) of active ingredients.

As with the other products we've featured on this list, we're glad to see that this supplement contains the essentials such as NAC and Hawthorne.

As we've told you before, we're convinced that some of these dosages are too low for them to work at full force. Nonetheless, it's a good product that does help you when you need it most.

For a bottle of Blackstone Labs's Gear Support, it's going to cost you roughly $40. Please note that it's advised to run it throughout your entire cycle, so you might need more than just one bottle.

6. Mutant

Mutant cycle support

We're finishing off this top 6 with Mutant by Xcel Sports Nutrition Supplements. We feel that it's not as popular as some of the other products mentioned on our list, but it's still a great option.

Mutant cycle support contains three blends, but it's the organ support we're interested in because that's what you came for. Let's take a look at the blend and what ingredients it contains:

  • 200mg Milk Thistle
  • 100mg N-Acetyl-L-Cysteine
  • 200mg Beta-Sitosterol
  • 250mg Saw Palmetto
  • 150mg Alpha Lipoic Acid
  • 75mg CoQ10
  • 150mg Hawthorne Berry

Total: 1,1 grams (1125mg) of active ingredients.

The variety of ingredients is good, but we consider the dosages too low for them to offer complete protection. Because of the insufficient dosages, it isn't the first product we would recommend.

With that said, we still find it offers some form of protection, just not optimally.

The Best On Cycle Support Ingredients

There's only several on cycle support ingredients that could work when it comes to protecting the organs. That means you should get a supplement that contains the ingredients below.

Allow us to show you some of the most potent ingredients.


TUDCA, short for Tauroursodeoxycholic acid, is an excellent compound to use on cycle. It naturally occurs in the body, but you need to get it through supplementation for the benefits.

TUDCA has shown to help reduce liver enzymes and might have regeneration abilities (5).

It's by far one of the most promising ingredients for cycle support products. Make sure the product you are getting includes this compound as it's the strongest one.

2. Milk Thistle

Milk Thistle, also known as Silymarin, is another highly effective ingredient that could offer protection when on a cycle. It's been around for centuries as a herbal remedy.

It is said to have hepatoprotective effects, precisely what you need when running performance enhancers (6). It also has antioxidant effects that could have other health benefits.

Milk Thistle Cycle Support Ingredients

Therefore, we find it to be a critical ingredient that must be included in liver cycle support products.

3. N-Acetyl-Cysteine

 N-Acetyl-Cysteine (NAC) is a metabolite of L-Cysteine. This compound is beneficial because it has antioxidant and anti-inflammatory effects (7).

It is also useful for protecting the liver and kidneys from potential damage (8). Since steroids, prohormones, and SARMs can damage the liver; it's crucial to prevent this by taking these kinds of ingredients.

I've shown you three of the best on cycle support ingredients. They can all offer some form of protection one way or the other.

This is why it's essential to get yourself a product that contains the above ingredients. 

The Best Liver Protection For Steroids

When you're running a cycle of AAS, you're going to want to know what the best liver protection for steroids is.

Why is this important?

Because many androgenic anabolic steroids (AAS) put the liver and kidneys under a lot of stress, more than prohormones or SARMs.

That's why we can't stress the importance of getting yourself a stacked and high-quality product. Yes, you might be spending a bit more money, but we're talking about the health of organs here.

In our opinion, Defend by Huge Nutrition is the best liver support for steroids. It has the best and most active ingredients, meaning you can't go wrong with it.

Best liver protection for steroids

Each serving is four capsules, which means you're getting double the amount of ingredients compared to other products out there.

You can get Defend (one month's supply) from the official site for just $49.95. It's a fair price considering you are getting a loaded supplement with a 4-capsule serving size.

We highly recommend stocking up on this product if you're planning or currently running a cycle. It's advised to run it for the entire duration of your cycle as well.

Do You Really Need Liver Support On Cycle?

In my opinion, every cycle with performance-enhancers requires a liver cycle support supplement.

It's between 50 to 100 bucks to use cycle support for the duration of your entire cycle. 

If you don't have that money for a crucial product like a liver cycle support, maybe you shouldn't be running a cycle in the first place.

In my opinion, it's definitely not a product you should cheap out on. At the end of the day, it's better to be safe than sorry.

If you're going to experience complications with the liver or kidneys, which is a serious possibility, you will regret not having used cycle support.

Also make sure to add in a post cycle therapy supplement like Rebirth

Do You Need Cycle Support For SARMs?

Selective androgen receptor modulators (SARMs) require cycle support, even though many people claim they aren't liver toxic.

Especially the more potent compounds out there can impact the organ. Our motto is better safe than sorry, and it's a wise idea to stock up on one.

For a cycle of SARMs, you can look at our top 6 mentioned above and pick one of those products to assist you during your cycle.

When To Take Cycle Support Supplements

The day you begin your run, that's when you start taking a cycle support supplement. If your cycle lasts for 8 weeks, you also run it alongside for 8 weeks.

Let's say you go with Defend, for example. The product's serving size is four capsules, and you have to take those capsules every day with a meal.

I take my dosage the first thing in the morning with my breakfast. You can take it a different time as it comes down to personal preference, as long as you don't skip a dosage.

The Bottom Line

We've shown you why on cycle support supplements are essential. They help protect your organs – you'll need those to be healthy for the rest of your life.

Those of you that want my advice, go with Defend by Huge Nutrition. It's an incredibly stacked product with a fair price, and use it for all my cycles.

Whichever product you decide to go with, make sure it contains scientifically backed ingredients such as TUDCA and Milk Thistle. They're the crucial compounds that will help massively.

This goes for every supplement, even pre-workout supplements. Check the label before buying it.

If you have tips on maintaining healthy lipids or blood pressure while running performance enhancers, share them in the comments.

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Kyle is passionate about bodybuilding and fitness. He has been training for over two decades and has trained and coached many people in the past. Kyle shares his experience on various supplements, health, and bodybuilding topics. He is a certified health coach and is the CEO of SupplementsReviewer.